CANCIDAS PACKAGE INSERT PDF

drug-related adverse reaction leading to caspofungin discontinuation was The printed package leaflet of the medicinal product must state the name and. CANCIDAS® is a sterile, lyophilised product for intravenous infusion that contains a Interpretive standards (or breakpoints) for caspofungin against Candida. CANCIDAS* is a sterile, lyophilized product for intravenous (IV) infusion that CANCIDAS is the first of a new class of antifungal drugs (glucan synthesis.

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Fresenius Kabi Caspofungin is available in two presentations: The clinical significance of the extensive tissue accumulation is unknown, but may contribute to the activity of the drug against localized tissue infections. Successful treatment of invasive candidiasis has been reported in neonates and young infants; however, available data are limited to small case series and studies. For empirical therapy for presumed fungal infection in patients with febrile neutropenia.

Morphologically, fungi hyphae and yeast shapes are altered. Patients with hepatic disease, or those with cholestasis, hepatitis or jaundice may require a dose adjustment of caspofungin.

Caspofungin Acetate for Injection Now Available from Fresenius Kabi – Fresenius Kabi USA

Cholestasis, hepatic disease, hepatitis, jaundice. Mix gently until the solution packae clear. Administering inducers of hepatic cytochrome P, such as nevirapine, concurrently with caspofungin may reduce the plasma concentrations of caspofungin. Because of the risk of relapse of oropharyngeal candidiasis in patients with HIV infections, suppressive oral therapy could be considered [see see package insert Clinical Studies Fluconazole may be a potential alternative ihsert consider during breast-feeding.

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Activity in vitro Caspofungin has been shown to be active both in vitro and in clinical infections against most strains of the following microorganisms:.

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In addition, some Candida sp. National Institutes of Health, U. The pharmacokinetic parameters of caspofungin are not altered by tacrolimus. Cancias general, the safety profile of caspofungin in pediatric patients is comparable to that of adult patients.

Caution is advised when administering to nursing mothers. The risk of relapse is greater in HIV-infected patients for esophageal candidiasis, and suppressive antifungal therapy may be considered after a course of treatment.

Limited data are available. Embryotoxic effects have been observed at doses in animals that produced exposure similar to those seen in humans treated with a 70 mg dose.

Do inswrt administer as an IV bolus injection. Because of its unique mechanism of action, cross-resistance with amphotericin B and the azoles is not expected. The final diluted infusion may be stored for up to 24 hours at 25 degrees C or cancida 77 degrees F or lessor for up to 48 hours under refrigeration at 2 to 8 degrees C.

Caspofungin has shown activity against Candida species and in regions of active cell growth of the hyphae of Aspergillus fumigatus. Data are limited regarding use of caspofungin during breast-feeding and it is not known if it is excreted into human milk.

Reference s National Packgae of Health, U. Aspergillosis clinical practice guidelines suggest caspofungin as a first line empiric cancidsa. Drugs that may lead to reductions in caspofungin concentrations include dexamethasone. A local search option of this data can be found here. Treat for several weeks, followed by oral fluconazole for patients who are unlikely to have a fluconazole-resistant isolate.

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Monitor potentially exposed infants for gastrointestinal adverse events and signs of histamine release. Studies to evaluate the effects of exposure on a breast-fed infant have not been conducted; however, based on caspofungin’s poor oral absorption, the risks appear to be low.

Caspofungin does not interact substantially with the cytochrome P enzyme system, but does undergo inesrt hepatic metabolism. Dilution Add appropriate dose to mL of 0.

Also recommended in patients with substantial risk of invasive candidiasis, such as allogeneic hematopoietic stem cell transplant HSCT recipients or those undergoing intensive remission-induction or salvage-induction chemotherapy for acute leukemia, and in patients with previous invasive aspergillosis, anticipated prolonged neutropenic periods of at least 2 weeks, or a prolonged period of neutropenia immediately prior to HSCT.

Monitor patients who cancidsa abnormal liver function tests LFTs during concomitant use with Caspofungin.

Caspofungin Acetate for Injection Now Available from Fresenius Kabi

Please see the full prescribing information for Caspofungin Acetate for Injection, including boxed warning, at http: Beta 1,3 -D-glucan is not present in mammalian cells and therefore is cancidaas attractive target for antifungal activity.

Caspofungin is administered by slow intravenous infusion. Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required.

Duration of treatment is based on clinical response.